Note: This is a review of the Funimation English dub of this series.

Violence / Gore:
Okami-san often punches/kicks people (especially when she is angry). She sometimes uses boxing gloves which leave cat-shaped marks on people's faces. This anime has various fight scenes. The only blood shown is limited (i.e. dripping down someone's face).
One guy gets intentionally kicked in the groin area. Some guys forcefully kick a girl in the stomach as she lies helpless on the ground.

Nudity / Sexual Content:
A girl is dared to kiss another girl and quickly does so (this is at the end of an episode after the ending theme song). One girl is said to have "a thing" for another girl. Another girl jokes that if her female friend "changed preferences" their friendship would end and be replaced by "maidenly true love."
One girl in the show often drags her boyfriend away and we are to assume they are having physical relations. During one of these scenes, the door the couple is behind starts shaking. We often hear the guy yelling in protest.
One guy cross-dresses a few times. There is also an episode where a group of guys dress as maids to cheer someone up.
Many comments about (and a lot of emphasis on) female bosoms. One character has a noticeably large chest and some guys often talk about her "dumplings." An older man talks about breast sizes and gravity. There are some swimsuit scenes that zero-in on female rear ends. One girl's top falls off but she's covered.
Girls/guys are shown nude in shower scenes - the important parts are covered by steam or towels. A girl falls down and her undies are shown. The same character later unbuttons her top and exposes her bra to a guy.
Some thugs try to take off a girl's shirt. Their comments make it sound as if they were trying to force themselves on her.
One character claims he raped a girl. Nothing is shown, and he seems to take back this statement later, although it's clear he did try to do something to her.
False rumors are started that a character is "sleeping around." A girl tells a guy that she will repay his kindness towards her by letting him be her "first."

Potentially problematic theological themes:
Some guys bow down to a girl because she has a large chest. Later, these same guys state that they will go "through fire and damnation" to thank the girl for having such a large chest.

Other potentially problematic themes:
Mild swearing (bi*** is the most commonly used word). Averages about 1 word per episode.

*
Okami-san is a comedy about a group of very different people working together to complete tasks for students who request their help. Though the humor doesn't always work and the content can be questionable, the changes in Ryoko and Ryoshi's interactions were refreshing to see. There was definitely some character growth buried in this series.